Каталог стандартов

+7 (495) 223-46-76 +7 (812) 309-78-59
inform@normdocs.ru

ASTM D7644-10e2

Заменен
Standard Test Method for Determination of Bromadiolone, Brodifacoum, Diphacinone and Warfarin in Water by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) — 15 стр.
Значение и использование

This test method has been developed by US EPA Region 5 Chicago Regional Laboratory (CRL).

Bromadiolone, brodifacoum, diphacinone and warfarin are rodenticides for controlling mice, rats, and other rodents that pose a threat to public health, critical habitats, native plants and animals, crops, food and water supplies. These rodenticides also present human and environmental safety concerns. Warfarin and diphacinone are first-generation anticoagulants, while bromadiolone and brodifacoum are second-generation. The anticoagulants interfere with blood clotting, and death can result from excessive bleeding. The second-generation anticoagulants are especially hazardous for several reasons. They are highly toxic and persist a long time in body tissues. The second-generation anticoagulants are designed to be toxic in a single feeding, but time-to-death occurs in several days. This allows rodents to feed multiple times before death, leading to carcasses containing residues that may be many times the lethal dose.

This method has been investigated for use with reagent, surface, and drinking water for the selected rodenticides.

Область применения

1.1 This procedure covers the determination of bromadiolone, brodifacoum, diphacinone and warfarin (referred to collectively as rodenticides in this test method) in water by direct injection using liquid chromatography (LC) and detected with tandem mass spectrometry (MS/MS). These analytes are qualitatively and quantitatively determined by this method. This method adheres to multiple reaction monitoring (MRM) mass spectrometry.

1.3 UnitsThe values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

TABLE 1 Detection Verification Level and Reporting Range

AnalyteDVL
(ng/L)Reporting Range
(ng/L) Bromadiolone20125-2500 Brodifacoum20125-2500 Diphacinone20125-2500 Warfarin20125-2500


FIG. 1 Example Primary SRM Chromatograms Signal/Noise Ratios


FIG. 2 Example Confirmatory SRM Chromatograms Signal/Noise Ratios

ICS
13.060.50 Examination of water for chemical substances / Исследование воды для определения содержания химических веществ
Сборник ASTM
11.02 Water (II) / Вода (II)
Тематика
Water Testing